Compared to an immune library, which is created after an animal is immunized with a specific antigen, a naïve sdAb library is created from unimmunized animals, so it represents a baseline collection of sdAbs that have not been biased by the immunization process. naïve sdAb libraries are therefore useful for discovering new binders and identifying unique target-specific antibodies that may be missed by immune libraries.

The advantages of a naïve sdAb library include lower costs, less time, and the potential to discover novel binders and unique target-specific binders from a diverse and unbiased collection, increasing the chance of identifying sdAbs for any given antigen.

NBbiolab provides high quality and super-trillion naïve sdAbs libraries derived from Alpaca, Llama and Camel,respectively. Combining with NBbiolab sdAbs screening platform, high affinity binders can be delivered as fast as within two to four weeks. 

Naïve sdAb library features:

· No animal immunization needed

· Requires diverse blood samples from different animals

· Can generate sdAbs targeting any specific antigen.

· Short turnaround time for rapid screening sdAbs